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KMID : 0604520160420040321
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Journal of the Society of Cosmetic Scientists of Korea
2016 Volume.42 No. 4 p.321 ~ p.328
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Isolation and Evaluation of Anti-oxidative Constituents from the Extracts of Ficus erecta var. sieboldii King Leaves
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Park Sung-Hwan
Kim Jung-Eun
Yeum Hyun-Sook
Lee Nam-Ho
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Abstract
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In this study, we investigated identification of anti-oxidative constituents from Ficus erecta var. sieboldii King (F. erecta) leaves. DPPH and ABTS+ radical scavenging activities were screened for the ethanol extract and solvent fractions, and ethyl acetate fraction showed the most potent scavenging activities. Five constituents were isolated from the ethyl acetate fraction of F. erecta leaves; monoolein (1), oleic acid (2), lutein (3), afzelechin (4), catechin (5). The chemical structures of the isolated compounds were elucidated based on the spectroscopic data including NMR spectra, as well as comparison of the data to the literature values. As far as we know, all of the compounds 1 ∼ 5 were isolated for the first time from this plant. Studies on DPPH and ABTS+ radical scavenging activities were conducted for the isolated compounds. Among them, afzelechin (4) and catechin (5) showed strong DPPH and ABTS+ radical scavenging activities, whose activities were comparable to a positive control vitamin C. Also, the content of catechin isolated from this plant was determined by HPLC and it was about 3.8 mg/g for the 70% ethanol extract and 20.8 mg/g for the ethyl acetate fraction. From these results, F. erecta leaves extract could be potentially applicable as anti-oxidant ingredients in cosmetic industries.
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KEYWORD
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Ficus erecta var. sieboldii, anti-oxidation, DPPH radical, ABTS radical, isolation
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